An in-depth analysis of the lack of effect of botulinum toxin type A treatment and the decline in its efficacy with long-term use. Causes of nonresponse or reduced effect with prolonged administration.

Xeomin has been used in clinical practice for more than 10 years, with over 127,000 people having received injections of this drug, and to date, not a single patient has been identified who failed to show a secondary clinical response.

The main methods of treating obesity are a calorie-restricted diet and a specially designed program of physical activity. However, many patients have to resort to pharmacotherapy or surgery.

The topic of Botox is marked equally by enthusiastic praise and harsh criticism. So what is it, after all — a “rejuvenating apple” or a “forbidden fruit”? The legendary Dr. Jean-Louis Sebagh and star cosmetologist Carmen Salvatore know the truth.

Millions of botulinum toxin injections have been performed worldwide. However, not all of them were done with contraindications taken into account, and not all patients were satisfied with the results.

Botox has become a generic name, just as we often call any photocopier a Xerox. Everyone — or almost everyone — knows about this wrinkle-treatment method. However, interest in alternative “non-injection approaches” is growing increasingly rapidly.